The second issue of the open-access journal showcases multidisciplinary heart failure research and the many intersections that shape patient care.

WASHINGTON, Nov. 19, 2025 /PRNewswire/ -- The second issue of the Journal of Cardiac Failure-Intersections, online now, delivers a diverse collection of original research and reviews that push forward understanding of heart failure mechanisms, clinical care, and multidisciplinary management. The issue spans topics from cost-effectiveness in CABG vs PCI in ischemic cardiomyopathy to insights from TOPCAT—and features a timely State-of-the-Art Review examining the evolving concept of right ventricular reserve (RVR).

Featured State-of-the-Art Review on Right Ventricular Reserve

Right Ventricular Reserve: A Scoping Review synthesizes emerging evidence on how the right ventricle responds to physiologic stress and why RVR may be a valuable marker of adaptability across cardiorespiratory diseases. Despite promising associations with clinical outcomes, the field lacks standardized definitions, consistent testing modalities, and validated imaging approaches. The authors outline current methods—ranging from invasive hemodynamic assessment to noninvasive stress imaging—and identify the gaps that must be addressed before RVR can be fully integrated into routine practice.

"We could not be more excited for our second issue because it reflects just how dynamic and multidisciplinary heart failure science has become," said Editor-in-Chief Jason N. Katz MD, MHS. "Our State-of-the-Art Review on right ventricular reserve explores an emerging hemodynamic concept that could meaningfully impact patient evaluation, but it also exemplifies the broader strength of this issue: rigorous studies, diverse topics, and insights that clinicians and researchers won't want to miss."

Also highlighted in the November issue are two Original Research Papers: Cost-effectiveness of Coronary Artery Bypass Grafting Versus Percutaneous Coronary Intervention in Severe Ischemic Cardiomyopathy and "It's Done its Job": A Qualitative Study of Interprofessional Clinicians' Perspectives on LVAD Deactivation

The full line-up for the Journal of Cardiac Failure-Intersections November 2025 issue is as follows:

Editor's Page

• Splendidly Ignorant and Uncertain

Original Research Papers

• Cost-effectiveness of Coronary Artery Bypass Grafting Versus Percutaneous Coronary Intervention in Severe Ischemic Cardiomyopathy
  • Editorial: Coronary Artery Bypass Grafting or Percutaneous Coronary Intervention in Ischemic Cardiomyopathy: Time to Settle the Score
• Anemia Is Associated With Incident Heart Failure in Younger Males
• Retrospective Review of the Safety and Effectiveness of a Low-carbohydrate Ketogenic Diet Intervention in Patients With Overweight or Obesity and Heart Failure
  • Editorial: Low-carbohydrate Ketogenic Diet in Patients with Heart Failure: Signals, Safeguards, and Next Steps
• "It's Done its Job": A Qualitative Study of Interprofessional Clinicians' Perspectives on LVAD Deactivation
• Balancing Autonomy and Moral Distress: The Complexities of LVAD Deactivation
• Outcomes Associated With Renal Replacement Therapy Use and Modality in Cardiogenic Shock Patients
  • Editorial: Renal Support and Outcomes in Cardiogenic Shock

State-of-the-Art Review

• Right Ventricular Reserve: A Scoping Review

Brief Report

• Smartphone-based AI-enhanced ECG Detection of Left Ventricular Systolic Dysfunction in Chagas Disease: External Validation in a Resource-limited Setting
• Impact of Ejection Fraction on Correlation Between Congestion Biomarkers and Blood Volume Measurements in Heart Failure

Research Letter

• Changes in Diastolic Parameters and Their Association With Changes in Health Status: Insights From TOPCAT

View the full issue online. For interviews with authors, please contact Laura Poko at lpoko@hfsa.org.

About the Journal of Cardiac Failure-Intersections

The Journal of Cardiac Failure-Intersections is an open-access journal with a focus on heart failure and its various intersections with other disciplines and specialties within the broader cardiovascular community. The journal has a special focus on how multidisciplinary partnerships impact patient care. Published papers will span original investigator-initiated work to state-of-the-art reviews, expert perspectives, including those with a global viewpoint, early career and trainee spotlight pieces, and patient and patient-partner narratives.

About the Heart Failure Society of America

The Heart Failure Society of America, Inc. (HFSA) represents the first organized effort by heart failure experts from the Americas to provide a forum for all those interested in heart function, heart failure, and congestive heart failure (CHF) research and patient care. The mission of HFSA is to provide a platform to improve and expand heart failure care through collaboration, education, innovation, research, and advocacy. HFSA members include physicians, scientists, nurses, nurse practitioners, pharmacists, trainees, other healthcare workers, and patients. For more information, visit hfsa.org.

Media Contact: Laura Poko, 301-798-4493, ext. 226, lpoko@hfsa.org 

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SOURCE Heart Failure Society of America